Non sedating muscle
Cyclobenzaprine and carisoprodol were compared in the treatment of patients with acute thoracolumbar pain and spasm rated moderate to severe and of no longer than seven days duration.
Both drugs were found to be effective, without significant differences between the treatment groups.
In an attempt to determine the mechanism of action of carisoprodol (Soma) in the treatment of low back pain, a double blind study was carried out comparing its effectiveness to that of a sedative control, butabarbital (a sedative), and a placebo in the treatment of 48 laborers with acute lumbar pain.
Drugs such as denosumab and the use of radionuclides are currently being explores in this respect.
During the ten-day study period, the combined treatment group demonstrated significantly superior improvements in global ratings on day four, but not on day two or seven.
This study suggested some effectiveness of combined analgesic and muscle relaxant therapy when utilized early in the initial week of pain onset.
For example, new formulations of drugs such as nasal sprays and sublingual tablets and the increasing use of adjuvant therapy to reduce the amount of opioid have widened the options available for pain management.
See separate article Pain Control in Palliative Care for more details. The Scottish Intercollegiate Guidelines Network (SIGN) reiterates that drugs should be initiated at the step in the analgesic ladder appropriate to the level of pain as dictated by a pain scale.
Professional Reference articles are written by UK doctors and are based on research evidence, UK and European Guidelines.